Distinguished Keynote Speaker III CMOS Electronics See Inside Biological Cellular Networks Dr. Donhee Ham Harvard University Wednesday, August 9, 2017, 08:00 – 09:00 Distler Hall, Granoff Music Center

Abstract. Realizing a closely packed electrode array capable of parallel + intracellular recording from a complex network of electrogenic cells has long been an outstanding challenge in neuroscience, cardiac technology, and bioengineering. Taking two notable examples, CMOS microelectrode arrays (MEAs) and planar patch-clamp arrays have brought tremendous impact in electrophysiology, but they have not been able to combine parallelism and intracellular measurements. Specifically, while the CMOS MEA enables network-level studies with massive parallelism, its extracellular interface cannot achieve high-fidelity features––such high signal-to-noise ratio, single-cell resolution, no signal distortion––of intracellular recording. On the other hand, while the planar patch-clamp array allows for high-precision intracellular access, it cannot achieve network-level parallelism. I would like to share our recent development of a nanoscale electrode array on a CMOS chip, which successfully combines network-level parallelism and intracellular interfacing [Nature Nanotechnology, 12, 460 (2017)]. I would also like to discuss the outlook of this unprecedented capability in a number of applications such as cellular-precision neuroprosthesis and brain-machine interface, and high-throughput pharmaceutical screening.

Donhee Ham is Gordon McKay Professor of Applied Physics and EE at Harvard University. He earned B.S. degree in physics from Seoul National University. Following a 1.5-year military service in the South Korea Army, he went to Caltech for graduate training in physics. There he worked in LIGO under Professor Barry Barish while in physics, and later obtained a Ph.D. in EE in 2002 winning the Charles Wilts Prize. He was the recipient of the IBM Doctoral Fellowship, Li Ming Scholarship, IBM Faculty Partnership Award, IBM Research Design Challenge Award, and the Korea Foundation of Advanced Studies Fellowship. For CMOS-based nuclear magnetism work, he was recognized by MIT Technology Review as among the world’s top 35 young innovators in 2008 (TR35). Ham was selected as a Harvard Yearbook Favorite Professor 4 years in a row (2011-2014), and was one of 8 Harvard Thinks Big speakers in 2012 (8 Harvard faculty chosen by college-wide votes). He served as an IEEE Distinguished Lecturer for the Solid-State Circuits Society (2012-2013). Ham’s work experiences include Caltech-MIT LIGO, IBM T. J. Watson Research, Consulting Visiting Professorship at POSTECH, Distinguished Visiting Professorship at Seoul National University, IEEE conference technical program committees including the IEEE ISSCC and the IEEE ASSCC, advisory board for the IEEE ISCAS, and various US, Korea, and Japan industry, government, & academic technical advisory positions. He served as a guest editor for the IEEE Journal of Solid-State Circuits and was a co-editor of CMOS Biotechnology with Springer (2007). He is an associate editor for IEEE Transactions on Biomedical Circuits and Systems. His current research focus is on: nano-bio interface array for neuroscience and molecular diagnostics; scalable biomolecular spectroscopy; 2D and quantum materials; and CMOS integrated circuits (RF, analog, and mixed-signal).